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タイトル Physiological roles of azuki bean (Vigna angularis) polyphenols in oxidative stress and inflammation in rats with hypertension
別タイトル
高血圧モデルラットの酸化ストレスおよび炎症におけるアズキ(Vigna angularis)ポリフェノールの生理的役割
Physiological roles of azuki bean (Vigna angularis) polyphenols in oxidative stress and inflammation in rats with hypertension ; 高血圧モデルラットの酸化ストレスおよび炎症におけるアズキ(Vigna angularis)ポリフェノールの生理的役割
著者
向井, 友花 (Mukai, Yuuka)
青森県立保健大学大学院健康科学研究科生活健康科学分野 (The Graduate School of Health Sciences Aomori University of Health and Welfare)
出版地 [青森]
上位タイトル
青森県立保健大学大学院博士論文. 2009年度 (2010. 3)
識別番号
その他
000011038178
博士論文情報
学位授与番号 21102A10
学位授与年月日 2010-03-18
学位名 博士(健康科学)
学位授与機関 青森県立保健大学
抄録 The aim of the present study was to examine whether azuki bean polyphenols would contribute to attenuation of hypertension, if so, to clarify the physiological role in oxidative stress and inflammation with hypertension.
Male spontaneously hypertensive rats/Izumo (SHR) and control normotensive WKY/Izumo (WKY) rats were randomly divided into 2 groups each, treated or untreated with polyphenols-containing azuki bean seed coats (ABSC) or extract (ABE). When the systolic blood pressure of SHR reached approximately 200 mmHg, they were administered each diet for 8 weeks. The blood pressure and heart rate were measured once every 2 weeks by the tail-cuff plethysmography method. The nitric oxide (NO) content in 24-h urine was measured by Griess method. After sacrifice, superoxide (O2) production in aorta was determined using a lucigenin-enhanced chemiluminescence technique. Vascular mRNA levels of NADPH oxidase subunits, Nox4, p47phox and p22phox, and monocyte chemoattractant protein 1 (MCP-1) and its receptor CCR2 were respectively analyzed by real-time RT-PCR. Vascular or renal protein levels of superoxide dismutase (SOD), endothelial NO synthase (eNOS), cavelin-1, inducible NOS (iNOS) and cyclooxygenase 2 (COX-2) were respectively analyzed by western blotting.
Azuki bean polyphenols such as procyanidin and catechin, contained in ABSC and ABE, reduced the elevated blood pressure in long-term treatment of SHR. ABSC treatment decreased the vascular production of O2, and suppressed the mRNA expression of the p47phox subunit of NADPH oxidase in the aorta. ABE treatment increased the renal Cu/Zn-SOD expressions. ABE treatment increased the urinary NOx content, indicating an increased NO production. ABE treatment modulated the eNOS and caveolin-1 expressions in the aorta and kidney of SHR. ABSC treatment suppressed the mRNA expressions of MCP-1, its receptor CCR2, and the protein expression of MCP-1. ABSC treatment suppressed the protein expressions of iNOS and COX-2 in the aorta of SHR. In conclusion, azuki bean polyphenols were showed to contribute to attenuation of oxidative stress and inflammation with hypertension. These effects may lead to prevention of NO inactivation and immune cells infiltration, associated with amelioration of endothelial dysfunction.
目次 List of Tables
List of Figures
Abstract
Chapter 1. General Introduction
Chapter 2. Supression of vascular and renal oxidative stress
2.1 Effect of azuki bean seed coats (ABSC) on superoxide production in
spontaneously hypertensive rats
2.2 Effect of azuki bean extract (ABE) on nitric oxide metabolism in
spontaneously hypertensive rats
2.3 Discussion
Chapter 3. Supression of vascular inflammation
3.1 Effect of azuki bean seed coats (ABSC) on vascular inflammation in
spontaneously hypertensive rats
3.2 Discussion
Chapter 4. General Discussion
Chapter 5. Conclusion
Acknowledgements
References
注記 取得学位:博士(健康科学)
報告番号:甲第10号
学位授与年月日:平成22年3月18日
指導教員:佐藤伸
言語
eng
資源タイプ text
ジャンル Thesis or Dissertation
著者版フラグ ETD
Index
/ Public / 博士論文 / 本文
関連アイテム
アイテムの概要
Physiological roles of azuki bean (Vigna angularis) polyphenols in oxidative stress and inflammation in rats with hypertension(高血圧モデルラットの酸化ストレスおよび炎症におけるアズキ(Vigna angularis)ポリフェノールの生理的役割) [論文要旨]
向井, 友花
青森県立保健大学大学院博士論文. 要旨. 2009年度.(2010.3)
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